| VA | From | Airport | To | Destination | Type | Distance miles | Frequency | Competitors | |
|---|---|---|---|---|---|---|---|---|---|
| NAE | EGPK | Prestwick | EGPO | Stornoway | Local | 172.1 | 0 | ||
| NAE | EGPK | Prestwick | EGNE | Retford - Gamston | Local | 184.6 | 0 | ||
| RSQ | EGPK | Prestwick | EBBR | Brussels National | Local | 427.1 | 1 | ||
| RSQ | EGPK | Prestwick | BIKF | Keflavik | Regional | 740.2 | 0 | ||
| SSF | EGPK | Prestwick | EGGP | Liverpool | Local | 144.1 | 0 | ||
| SSF | EGPK | Prestwick | EGNX | East Midlands | Local | 197.4 | 1 | ||
| UFA | EGPK | Prestwick | SBGL | Rio De Janeiro - Galeao-Antonio C Jobim Intl | Long | 5096.8 | 0 | ||
| UFA | EGPK | Prestwick | YPDN | Darwin Intl | Long | 7491.1 | 0 | ||
| UFA | EGPK | Prestwick | VHHH | Hong Kong Intl | Long | 5183.9 | 0 | ||
| UFA | EGPK | Prestwick | LFPG | Paris - Charles-De-Gaulle | Local | 469.5 | 2 | ||
| UFA | EGPK | Prestwick | KDTW | Detroit Metro Wayne Co | Long | 3032.4 | 0 |