| VA | From | Airport | To | Destination | Type | Distance miles | Frequency | Competitors | |
|---|---|---|---|---|---|---|---|---|---|
| CIF | FPST | Sao Tome International | FYWB | Walvis Bay | Medium | 1476.0 | 0 | ||
| CIF | FPST | Sao Tome International | FN19 | Cabo Ledo | Regional | 717.7 | 0 | ||
| CIF | FPST | Sao Tome International | HTZA | Zanzibar - Kisauni | Medium | 1986.8 | 0 | ||
| CIF | FPST | Sao Tome International | HCMK | Kisimayu | Medium | 2144.8 | 1 | ||
| CIF | FPST | Sao Tome International | FEFF | Bangui - Mpoko | Regional | 747.6 | 1 | ||
| IFR | FPST | Sao Tome International | FOOL | Libreville - Leon Mba | Local | 162.0 | 0 |