| VA | From | Airport | To | Destination | Type | Distance miles | Frequency | Competitors | |
|---|---|---|---|---|---|---|---|---|---|
| CFC | KBUF | Buffalo Niagara Intl | KPHL | Philadelphia Intl | Local | 242.0 | 4 | ||
| CFC | KBUF | Buffalo Niagara Intl | KSYR | Syracuse Hancock Intl | Local | 115.6 | 3 | ||
| CFC | KBUF | Buffalo Niagara Intl | KDTW | Detroit Metro Wayne Co | Local | 208.8 | 5 | ||
| CFC | KBUF | Buffalo Niagara Intl | KCLE | Cleveland-Hopkins Intl | Local | 166.2 | 5 | ||
| CFC | KBUF | Buffalo Niagara Intl | KDFW | Dallas-Ft Worth Intl | Medium | 1051.7 | 3 | ||
| CFC | KBUF | Buffalo Niagara Intl | KORD | Chicago-OHare Intl | Local | 409.9 | 6 | ||
| CFC | KBUF | Buffalo Niagara Intl | CYYZ | Toronto/Pearson Intl | Local | 59.1 | 5 | ||
| CFC | KBUF | Buffalo Niagara Intl | KJFK | New York - Kennedy Intl | Local | 261.0 | 5 | ||
| EVO | KBUF | Buffalo Niagara Intl | KORD | Chicago-OHare Intl | Local | 409.9 | 0 | ||
| FAA | KBUF | Buffalo Niagara Intl | KACY | Atlantic City Intl | Local | 280.7 | 0 | ||
| FAA | KBUF | Buffalo Niagara Intl | KOMA | Omaha - Eppley | Regional | 768.7 | 1 | ||
| FTS | KBUF | Buffalo Niagara Intl | KDFW | Dallas-Ft Worth Intl | Medium | 1051.7 | 0 | ||
| FTS | KBUF | Buffalo Niagara Intl | KCLT | Charlotte/Douglas Intl | Local | 474.8 | 0 | ||
| FTS | KBUF | Buffalo Niagara Intl | KBOS | Boston - Logan Intl | Local | 342.6 | 1 | ||
| FTS | KBUF | Buffalo Niagara Intl | KATL | The Hartsfield Atlanta Intl | Regional | 618.7 | 0 | ||
| FTS | KBUF | Buffalo Niagara Intl | KMIA | Miami Intl | Medium | 1031.7 | 1 | ||
| FTS | KBUF | Buffalo Niagara Intl | KPIT | Pittsburgh Intl | Local | 161.6 | 0 | ||
| FTS | KBUF | Buffalo Niagara Intl | KORD | Chicago-OHare Intl | Local | 409.9 | 0 | ||
| FTS | KBUF | Buffalo Niagara Intl | KJFK | New York - Kennedy Intl | Local | 261.0 | 0 | ||
| NAE | KBUF | Buffalo Niagara Intl | KIND | Indianapolis Intl | Local | 391.6 | 1 | ||
| NAE | KBUF | Buffalo Niagara Intl | KRSW | Ft Myers - Southwest Florida Intl | Regional | 995.3 | 0 | ||
| SCA | KBUF | Buffalo Niagara Intl | KMDT | Harrisburg Intl | Local | 187.0 | 0 | ||
| SCA | KBUF | Buffalo Niagara Intl | KJFK | New York - Kennedy Intl | Local | 261.0 | 1 | ||
| SCA | KBUF | Buffalo Niagara Intl | KGLS | Scholes Intl At Galveston | Medium | 1129.4 | 0 | ||
| SCA | KBUF | Buffalo Niagara Intl | KPUB | Pueblo Meml | Medium | 1201.1 | 0 | ||
| SKA | KBUF | Buffalo Niagara Intl | KBOS | Boston - Logan Intl | Local | 342.6 | 0 | ||
| SKA | KBUF | Buffalo Niagara Intl | KMIA | Miami Intl | Medium | 1031.7 | 1 | ||
| SKA | KBUF | Buffalo Niagara Intl | KTPA | Tampa Intl | Regional | 916.6 | 0 | ||
| SKA | KBUF | Buffalo Niagara Intl | KJFK | New York - Kennedy Intl | Local | 261.0 | 2 | ||
| SKA | KBUF | Buffalo Niagara Intl | TNCM | St Maarten I - Princess Juliana Intl | Medium | 1691.8 | 1 | ||
| SKA | KBUF | Buffalo Niagara Intl | KSFO | San Francisco Intl | Medium | 2000.2 | 2 | ||
| SKA | KBUF | Buffalo Niagara Intl | KORD | Chicago-OHare Intl | Local | 409.9 | 0 | ||
| SKA | KBUF | Buffalo Niagara Intl | KLGA | New York - La Guardia | Local | 252.9 | 0 | ||
| SKA | KBUF | Buffalo Niagara Intl | KPHL | Philadelphia Intl | Local | 242.0 | 0 |