| VA | From | Airport | To | Destination | Type | Distance miles | Frequency | Competitors | |
|---|---|---|---|---|---|---|---|---|---|
| AVL | KDSM | Des Moines Intl | KLAX | Los Angeles Intl | Medium | 1253.9 | 0 | ||
| AVL | KDSM | Des Moines Intl | KORD | Chicago-OHare Intl | Local | 259.0 | 1 | ||
| CFC | KDSM | Des Moines Intl | KORD | Chicago-OHare Intl | Local | 259.0 | 4 | ||
| CFC | KDSM | Des Moines Intl | KMSP | Minneapolis-St Paul Intl | Local | 201.9 | 3 | ||
| CFC | KDSM | Des Moines Intl | KLNK | Lincoln Mun | Local | 145.7 | 3 | ||
| CFC | KDSM | Des Moines Intl | KMLI | Moline - Quad-City Intl. | Local | 141.9 | 4 | ||
| CFC | KDSM | Des Moines Intl | KRFD | Greater Rockford | Local | 207.8 | 4 | ||
| JUL | KDSM | Des Moines Intl | PHNL | Honolulu Intl | Long | 3423.0 | 0 | ||
| JUL | KDSM | Des Moines Intl | VHHH | Hong Kong Intl | Long | 6673.9 | 1 |