| VA | From | Airport | To | Destination | Type | Distance miles | Frequency | Competitors | |
|---|---|---|---|---|---|---|---|---|---|
| CFC | KEYW | Key West Intl | KMIA | Miami Intl | Local | 109.0 | 4 | ||
| EVO | KEYW | Key West Intl | MUKW | MUKW | Local | 89.6 | 0 | ||
| EVO | KEYW | Key West Intl | MUSJ | Pinar Del Rio - San Julian | Local | 197.9 | 0 | ||
| FAA | KEYW | Key West Intl | EGLL | London - Heathrow | Long | 3944.5 | 0 | ||
| KSA | KEYW | Key West Intl | EGCC | Manchester | Long | 3862.4 | 0 | ||
| OSA | KEYW | Key West Intl | KMIA | Miami Intl | Local | 109.0 | 0 | ||
| OSA | KEYW | Key West Intl | KDAB | Daytona Beach Intl | Local | 280.0 | 1 | ||
| SCA | KEYW | Key West Intl | KMCO | Orlando Intl | Local | 233.7 | 0 | ||
| SCA | KEYW | Key West Intl | KPHL | Philadelphia Intl | Regional | 976.0 | 0 |