| VA | From | Airport | To | Destination | Type | Distance miles | Frequency | Competitors | |
|---|---|---|---|---|---|---|---|---|---|
| USA | KMDH | Carbondale-Murphysboro - Southern Illinois | KPWK | Chicago/Prospect Hgts/W - Palwaukee Mun | Local | 267.5 | 0 | ||
| USA | KMDH | Carbondale-Murphysboro - Southern Illinois | KEVV | Evansville Regl | Local | 83.0 | 0 | ||
| USA | KMDH | Carbondale-Murphysboro - Southern Illinois | KSTL | Lambert-St Louis Intl | Local | 78.2 | 0 |