| VA | From | Airport | To | Destination | Type | Distance miles | Frequency | Competitors | |
|---|---|---|---|---|---|---|---|---|---|
| CFC | KPIE | St Petersburg-Clearwater Intl | KRSW | Ft Myers - Southwest Florida Intl | Local | 96.3 | 4 | ||
| FAA | KPIE | St Petersburg-Clearwater Intl | KPHX | Phoenix Sky Harbor Intl | Medium | 1543.7 | 1 | ||
| FAA | KPIE | St Petersburg-Clearwater Intl | CYUL | Montreal Intl (Dorval) | Medium | 1136.2 | 0 | ||
| FAA | KPIE | St Petersburg-Clearwater Intl | ZGGG | Guangzhou - Baiyun | Long | 7585.8 | 0 | ||
| IFR | KPIE | St Petersburg-Clearwater Intl | KJFK | New York - Kennedy Intl | Regional | 881.1 | 0 | ||
| IFR | KPIE | St Petersburg-Clearwater Intl | MPTO | Panama City - Tocumen Intl | Medium | 1145.7 | 0 | ||
| IMS | KPIE | St Petersburg-Clearwater Intl | OBBI | Bahrain Intl | Long | 6579.7 | 1 | ||
| NAE | KPIE | St Petersburg-Clearwater Intl | KHOU | Houston - Hobby | Regional | 670.0 | 0 | ||
| NAE | KPIE | St Petersburg-Clearwater Intl | SBGL | Rio De Janeiro - Galeao-Antonio C Jobim Intl | Long | 3804.4 | 0 | ||
| NAE | KPIE | St Petersburg-Clearwater Intl | EFHK | Helsinki - Vantaa | Long | 4445.9 | 0 | ||
| NAE | KPIE | St Petersburg-Clearwater Intl | EGLL | London - Heathrow | Long | 3831.2 | 1 | ||
| NAE | KPIE | St Petersburg-Clearwater Intl | LFMN | Nice/Cote dAzur | Long | 4264.7 | 1 | ||
| NAE | KPIE | St Petersburg-Clearwater Intl | KPIT | Pittsburgh Intl | Regional | 764.5 | 2 | ||
| NAE | KPIE | St Petersburg-Clearwater Intl | KBOS | Boston - Logan Intl | Medium | 1037.3 | 1 | ||
| NAE | KPIE | St Petersburg-Clearwater Intl | TNCM | St Maarten I - Princess Juliana Intl | Medium | 1230.5 | 0 | ||
| NAE | KPIE | St Petersburg-Clearwater Intl | KMCO | Orlando Intl | Local | 79.3 | 0 | ||
| NAE | KPIE | St Petersburg-Clearwater Intl | CYYC | Calgary Intl | Medium | 1982.9 | 0 | ||
| NAE | KPIE | St Petersburg-Clearwater Intl | KMEM | Memphis Intl | Regional | 567.3 | 2 | ||
| NAE | KPIE | St Petersburg-Clearwater Intl | KDFW | Dallas-Ft Worth Intl | Regional | 799.7 | 0 | ||
| NAE | KPIE | St Petersburg-Clearwater Intl | KSWF | Newburgh - Stewart Intl | Regional | 917.7 | 0 | ||
| NAE | KPIE | St Petersburg-Clearwater Intl | KDEN | Denver Intl | Medium | 1303.3 | 1 | ||
| NAE | KPIE | St Petersburg-Clearwater Intl | KABQ | Albuquerque Intl Sunport | Medium | 1292.8 | 0 | ||
| NAE | KPIE | St Petersburg-Clearwater Intl | KPSP | Palm Springs Intl | Medium | 1769.3 | 1 | ||
| NAE | KPIE | St Petersburg-Clearwater Intl | KFWA | Ft Wayne Intl | Regional | 793.7 | 0 | ||
| NAE | KPIE | St Petersburg-Clearwater Intl | MUHA | Havana - Jose Marti Intl | Local | 295.7 | 0 | ||
| NAE | KPIE | St Petersburg-Clearwater Intl | KMSY | New Orleans Intl | Local | 416.5 | 0 | ||
| NAE | KPIE | St Petersburg-Clearwater Intl | URSS | Sochi | Long | 5482.9 | 0 | ||
| NAE | KPIE | St Petersburg-Clearwater Intl | KDLH | Duluth Intl | Medium | 1220.8 | 1 | ||
| RED | KPIE | St Petersburg-Clearwater Intl | SPIM | Lima-Callao - Jorge Chavez Intl | Medium | 2417.7 | 0 |