| VA | From | Airport | To | Destination | Type | Distance miles | Frequency | Competitors | |
|---|---|---|---|---|---|---|---|---|---|
| AVL | KPIT | Pittsburgh Intl | KORD | Chicago-OHare Intl | Local | 357.3 | 2 | ||
| AVL | KPIT | Pittsburgh Intl | KLAX | Los Angeles Intl | Medium | 1850.8 | 0 | ||
| CFC | KPIT | Pittsburgh Intl | KCLE | Cleveland-Hopkins Intl | Local | 91.7 | 6 | ||
| CFC | KPIT | Pittsburgh Intl | KMDT | Harrisburg Intl | Local | 159.7 | 4 | ||
| CFC | KPIT | Pittsburgh Intl | KIND | Indianapolis Intl | Local | 282.0 | 8 | ||
| FTS | KPIT | Pittsburgh Intl | KBUF | Buffalo Niagara Intl | Local | 161.6 | 0 | ||
| FTS | KPIT | Pittsburgh Intl | KBOS | Boston - Logan Intl | Local | 429.8 | 0 | ||
| JUL | KPIT | Pittsburgh Intl | CYOW | Ottawa/Macdonald-Cartier Intl | Local | 352.3 | 0 | ||
| JUL | KPIT | Pittsburgh Intl | KORD | Chicago-OHare Intl | Local | 357.3 | 1 | ||
| JUL | KPIT | Pittsburgh Intl | KMIA | Miami Intl | Regional | 881.9 | 1 | ||
| KSA | KPIT | Pittsburgh Intl | KBOS | Boston - Logan Intl | Local | 429.8 | 1 | ||
| KSA | KPIT | Pittsburgh Intl | KORD | Chicago-OHare Intl | Local | 357.3 | 1 | ||
| NAE | KPIT | Pittsburgh Intl | KPIE | St Petersburg-Clearwater Intl | Regional | 764.5 | 0 | ||
| NAE | KPIT | Pittsburgh Intl | SBGR | Sao Paulo - Guarulhos Intl. | Long | 4273.5 | 2 | ||
| NAE | KPIT | Pittsburgh Intl | CYXE | Saskatoon/Diefenbaker | Medium | 1290.1 | 0 | ||
| NAE | KPIT | Pittsburgh Intl | MWCR | Grand Cayman - Roberts Intl | Medium | 1273.3 | 2 | ||
| SAA | KPIT | Pittsburgh Intl | TXKF | Bermuda Is - Bermuda Intl | Regional | 893.3 | 1 |