| VA | From | Airport | To | Destination | Type | Distance miles | Frequency | Competitors | |
|---|---|---|---|---|---|---|---|---|---|
| AAW | KRDU | Raleigh/Durham - Raleigh-Durham Intl | KSTL | Lambert-St Louis Intl | Regional | 578.0 | 1 | ||
| AAW | KRDU | Raleigh/Durham - Raleigh-Durham Intl | KDAL | Dallas Love | Regional | 911.6 | 0 | ||
| AVL | KRDU | Raleigh/Durham - Raleigh-Durham Intl | KORD | Chicago-OHare Intl | Regional | 560.8 | 2 | ||
| AVL | KRDU | Raleigh/Durham - Raleigh-Durham Intl | KLAX | Los Angeles Intl | Medium | 1939.6 | 0 | ||
| FAA | KRDU | Raleigh/Durham - Raleigh-Durham Intl | KACY | Atlantic City Intl | Local | 293.4 | 0 | ||
| OSA | KRDU | Raleigh/Durham - Raleigh-Durham Intl | KMIA | Miami Intl | Regional | 610.0 | 0 | ||
| OSA | KRDU | Raleigh/Durham - Raleigh-Durham Intl | KLAS | Las Vegas - McCarran Intl | Medium | 1755.2 | 1 | ||
| SCA | KRDU | Raleigh/Durham - Raleigh-Durham Intl | KPHL | Philadelphia Intl | Local | 292.6 | 0 | ||
| SCA | KRDU | Raleigh/Durham - Raleigh-Durham Intl | PHNL | Honolulu Intl | Long | 4151.1 | 0 | ||
| SCA | KRDU | Raleigh/Durham - Raleigh-Durham Intl | KATL | The Hartsfield Atlanta Intl | Local | 308.6 | 0 | ||
| SCA | KRDU | Raleigh/Durham - Raleigh-Durham Intl | KHEG | Herlong | Local | 368.6 | 0 | ||
| SCA | KRDU | Raleigh/Durham - Raleigh-Durham Intl | KLAX | Los Angeles Intl | Medium | 1939.6 | 0 | ||
| SCA | KRDU | Raleigh/Durham - Raleigh-Durham Intl | CYPD | Port Hawkesbury | Regional | 981.8 | 0 | ||
| SCA | KRDU | Raleigh/Durham - Raleigh-Durham Intl | KBRO | Brownsville/South Padre I Int | Medium | 1127.8 | 0 | ||
| SCA | KRDU | Raleigh/Durham - Raleigh-Durham Intl | KSAV | Savannah Intl | Local | 255.0 | 0 | ||
| SCA | KRDU | Raleigh/Durham - Raleigh-Durham Intl | KMCO | Orlando Intl | Local | 464.8 | 0 | ||
| SCA | KRDU | Raleigh/Durham - Raleigh-Durham Intl | KLAS | Las Vegas - McCarran Intl | Medium | 1755.2 | 0 | ||
| SCA | KRDU | Raleigh/Durham - Raleigh-Durham Intl | KJFK | New York - Kennedy Intl | Local | 370.4 | 0 | ||
| SCA | KRDU | Raleigh/Durham - Raleigh-Durham Intl | EGLL | London - Heathrow | Long | 3354.1 | 0 | ||
| SCA | KRDU | Raleigh/Durham - Raleigh-Durham Intl | PHKO | Kailua-Kona - Kona Intl At Keahole | Long | 4111.3 | 0 | ||
| SCA | KRDU | Raleigh/Durham - Raleigh-Durham Intl | TNCM | St Maarten I - Princess Juliana Intl | Medium | 1355.5 | 0 | ||
| SCA | KRDU | Raleigh/Durham - Raleigh-Durham Intl | KMIA | Miami Intl | Regional | 610.0 | 0 | ||
| SCA | KRDU | Raleigh/Durham - Raleigh-Durham Intl | KDFW | Dallas-Ft Worth Intl | Regional | 919.7 | 0 | ||
| SCA | KRDU | Raleigh/Durham - Raleigh-Durham Intl | KBOS | Boston - Logan Intl | Regional | 531.2 | 0 | ||
| SCA | KRDU | Raleigh/Durham - Raleigh-Durham Intl | PANC | Stevens Anchorage Intl | Long | 3015.7 | 0 | ||
| USA | KRDU | Raleigh/Durham - Raleigh-Durham Intl | KILM | Wilmington Intl | Local | 105.8 | 0 | ||
| USA | KRDU | Raleigh/Durham - Raleigh-Durham Intl | KJFK | New York - Kennedy Intl | Local | 370.4 | 0 | ||
| USA | KRDU | Raleigh/Durham - Raleigh-Durham Intl | KMCO | Orlando Intl | Local | 464.8 | 1 | ||
| USA | KRDU | Raleigh/Durham - Raleigh-Durham Intl | TXKF | Bermuda Is - Bermuda Intl | Regional | 731.0 | 1 | ||
| USA | KRDU | Raleigh/Durham - Raleigh-Durham Intl | KORL | Orlando - Executive | Local | 458.5 | 0 |