| VA | From | Airport | To | Destination | Type | Distance miles | Frequency | Competitors | |
|---|---|---|---|---|---|---|---|---|---|
| FAA | KSFB | Orlando Sanford | MKJS | Montego Bay - Sangster Intl | Regional | 642.8 | 0 | ||
| FAA | KSFB | Orlando Sanford | EGBB | Birmingham | Long | 3682.3 | 1 | ||
| FAA | KSFB | Orlando Sanford | KJAX | Jacksonville Intl | Local | 105.6 | 0 | ||
| FAA | KSFB | Orlando Sanford | KSRQ | Sarasota-Bradenton Intl - Sarasota-Bradenton | Local | 108.3 | 0 | ||
| SSF | KSFB | Orlando Sanford | KMIA | Miami Intl | Local | 186.1 | 0 | ||
| SSF | KSFB | Orlando Sanford | KSDF | Louisville Intl-Standiford | Regional | 606.9 | 1 |