| VA | From | Airport | To | Destination | Type | Distance miles | Frequency | Competitors | |
|---|---|---|---|---|---|---|---|---|---|
| CFC | KSUX | Sioux City - Sioux Gateway | KORD | Chicago-OHare Intl | Local | 377.7 | 3 | ||
| CFC | KSUX | Sioux City - Sioux Gateway | FAOR | Johannesburg Intl | Long | 7941.3 | 2 | ||
| CFC | KSUX | Sioux City - Sioux Gateway | KOFF | Omaha - Offutt AFB | Local | 79.9 | 2 | ||
| NAE | KSUX | Sioux City - Sioux Gateway | KJFK | New York - Kennedy Intl | Medium | 1018.0 | 0 | ||
| NAE | KSUX | Sioux City - Sioux Gateway | KMSY | New Orleans Intl | Regional | 800.9 | 0 | ||
| NAE | KSUX | Sioux City - Sioux Gateway | MSLP | San Salvador - El Salvador Intl | Medium | 1778.7 | 1 | ||
| NAE | KSUX | Sioux City - Sioux Gateway | KINW | Winslow-Lindbergh Regl | Regional | 802.5 | 0 |