| VA | From | Airport | To | Destination | Type | Distance miles | Frequency | Competitors | |
|---|---|---|---|---|---|---|---|---|---|
| AVL | KTYS | Knoxville - McGhee Tyson | KORD | Chicago-OHare Intl | Local | 412.5 | 1 | ||
| AVL | KTYS | Knoxville - McGhee Tyson | KLAX | Los Angeles Intl | Medium | 1689.0 | 0 | ||
| EVO | KTYS | Knoxville - McGhee Tyson | KSLC | Salt Lake City Intl | Medium | 1344.9 | 0 | ||
| EVO | KTYS | Knoxville - McGhee Tyson | CYMX | Montreal Intl (Mirabel) | Regional | 744.0 | 0 | ||
| EVO | KTYS | Knoxville - McGhee Tyson | KNQX | Key West NAS | Regional | 684.7 | 0 | ||
| FLW | KTYS | Knoxville - McGhee Tyson | KLGA | New York - La Guardia | Regional | 561.5 | 0 | ||
| NAE | KTYS | Knoxville - McGhee Tyson | KJFK | New York - Kennedy Intl | Regional | 561.4 | 0 | ||
| NAE | KTYS | Knoxville - McGhee Tyson | KMBS | Saginaw - Mbs Intl | Local | 463.3 | 1 | ||
| NAE | KTYS | Knoxville - McGhee Tyson | KBOS | Boston - Logan Intl | Regional | 720.2 | 0 | ||
| NAE | KTYS | Knoxville - McGhee Tyson | KLNK | Lincoln Mun | Regional | 671.7 | 0 |