| VA | From | Airport | To | Destination | Type | Distance miles | Frequency | Competitors | |
|---|---|---|---|---|---|---|---|---|---|
| AAW | LGSM | Samos | LXGB | Gibraltar AB | Medium | 1542.7 | 0 | ||
| AAW | LGSM | Samos | KDFW | Dallas-Ft Worth Intl | Long | 5534.1 | 0 | ||
| AAW | LGSM | Samos | KBOS | Boston - Logan Intl | Long | 4238.6 | 1 | ||
| SKA | LGSM | Samos | EDDN | Nürnberg | Regional | 983.8 | 1 | ||
| SKA | LGSM | Samos | EDDS | Stuttgart | Medium | 1012.7 | 1 | ||
| SKA | LGSM | Samos | LGKR | Kerkira - Ioannis Kapodistrias | Local | 347.4 | 0 | ||
| SKA | LGSM | Samos | LIRN | Naples - Capodichino Mil | Regional | 616.0 | 1 | ||
| SKA | LGSM | Samos | EDDB | Berlin - Schonefeld | Medium | 1044.7 | 1 | ||
| SKA | LGSM | Samos | EDDH | Hamburg | Medium | 1184.5 | 0 |