| VA | From | Airport | To | Destination | Type | Distance miles | Frequency | Competitors | |
|---|---|---|---|---|---|---|---|---|---|
| AAA | LGSR | Santorini | EGLL | London - Heathrow | Medium | 1427.1 | 0 | ||
| AAA | LGSR | Santorini | OMDB | Dubai Intl | Medium | 1669.8 | 1 | ||
| EVO | LGSR | Santorini | SBGL | Rio De Janeiro - Galeao-Antonio C Jobim Intl | Long | 5265.5 | 0 | ||
| FAA | LGSR | Santorini | LPMA | Madeira | Medium | 2083.6 | 0 | ||
| FAA | LGSR | Santorini | LLBG | Tel Aviv - Ben Gurion | Regional | 535.2 | 1 | ||
| RSQ | LGSR | Santorini | KFLL | Ft Lauderdale-Hollywood Intl | Long | 5173.0 | 0 | ||
| RSQ | LGSR | Santorini | LFPO | Paris - Orly | Medium | 1252.3 | 1 | ||
| SKA | LGSR | Santorini | LICR | Reggio Calabria | Local | 479.7 | 0 | ||
| SKA | LGSR | Santorini | EDDH | Hamburg | Medium | 1219.1 | 1 | ||
| SKA | LGSR | Santorini | LOWW | Vienna - Schwechat | Regional | 805.1 | 0 | ||
| SKA | LGSR | Santorini | LIRN | Naples - Capodichino Mil | Regional | 588.7 | 1 | ||
| SSF | LGSR | Santorini | EGPH | Edinburgh | Medium | 1654.5 | 0 | ||
| SSF | LGSR | Santorini | EGLL | London - Heathrow | Medium | 1427.1 | 0 | ||
| SSF | LGSR | Santorini | LICC | Catania - Fontanarossa | Regional | 503.3 | 0 | ||
| SSF | LGSR | Santorini | LCLK | Larnaca Intl | Local | 407.7 | 2 | ||
| SSF | LGSR | Santorini | LGIR | Iraklion - Nikos Kazantzakis | Local | 65.2 | 0 | ||
| SSF | LGSR | Santorini | EDLV | Niederrhein | Medium | 1228.8 | 0 | ||
| SSF | LGSR | Santorini | LIBR | Brindisi - Casale Mil | Local | 436.0 | 0 |