| VA | From | Airport | To | Destination | Type | Distance miles | Frequency | Competitors | |
|---|---|---|---|---|---|---|---|---|---|
| ACF | MDSD | Santo Domingo - Las Americas Intl | MKJS | Montego Bay - Sangster Intl | Local | 469.2 | 0 | ||
| ACF | MDSD | Santo Domingo - Las Americas Intl | TNCA | Aruba I - Oranjestad/Reina Beatrix Intl | Local | 356.3 | 3 | ||
| CIF | MDSD | Santo Domingo - Las Americas Intl | LFPG | Paris - Charles-De-Gaulle | Long | 3876.9 | 0 | ||
| CIF | MDSD | Santo Domingo - Las Americas Intl | NFFN | Nadi Intl | Long | 6996.2 | 1 | ||
| FTS | MDSD | Santo Domingo - Las Americas Intl | MKJS | Montego Bay - Sangster Intl | Local | 469.2 | 1 | ||
| FTS | MDSD | Santo Domingo - Las Americas Intl | KMIA | Miami Intl | Regional | 736.8 | 1 | ||
| IFR | MDSD | Santo Domingo - Las Americas Intl | TJSJ | San Juan - Luis Munoz Marin Intl | Local | 208.7 | 0 | ||
| IFR | MDSD | Santo Domingo - Las Americas Intl | MNMG | Managua - Augusto Cesar Sandino | Medium | 1026.0 | 0 | ||
| IFR | MDSD | Santo Domingo - Las Americas Intl | MTPP | Port-Au-Prince Intl | Local | 149.7 | 0 | ||
| IFR | MDSD | Santo Domingo - Las Americas Intl | MMAA | Acapulco - Gen Juan N Alvarez Intl | Medium | 1721.7 | 0 | ||
| IFR | MDSD | Santo Domingo - Las Americas Intl | MMCU | Chihuahua - Gen Div P A Roberto Fierro | Medium | 2079.7 | 0 | ||
| NAE | MDSD | Santo Domingo - Las Americas Intl | TNCM | St Maarten I - Princess Juliana Intl | Local | 374.5 | 0 | ||
| NAE | MDSD | Santo Domingo - Las Americas Intl | OMDB | Dubai Intl | Long | 6657.5 | 1 | ||
| OSA | MDSD | Santo Domingo - Las Americas Intl | KMIA | Miami Intl | Regional | 736.8 | 2 | ||
| OSA | MDSD | Santo Domingo - Las Americas Intl | GMMN | Casablanca - Mohamed V | Long | 3419.4 | 0 | ||
| OSA | MDSD | Santo Domingo - Las Americas Intl | GVAC | Sal - Amilcar Cabral | Medium | 2666.8 | 0 | ||
| OSA | MDSD | Santo Domingo - Las Americas Intl | EFRO | Rovaniemi | Long | 4517.5 | 1 | ||
| OSA | MDSD | Santo Domingo - Las Americas Intl | SBSP | Sao Paulo - Congonhas Intl | Medium | 2860.5 | 1 | ||
| OSA | MDSD | Santo Domingo - Las Americas Intl | TFFR | Pointe-A-Pitre - Le Raizet | Local | 484.1 | 3 | ||
| OSA | MDSD | Santo Domingo - Las Americas Intl | TBPB | Barbados - Grantley Adams Intl | Regional | 669.5 | 1 | ||
| RSQ | MDSD | Santo Domingo - Las Americas Intl | EDDM | Munich | Long | 4244.2 | 0 | ||
| RSQ | MDSD | Santo Domingo - Las Americas Intl | EDDL | Dusseldorf | Long | 4037.9 | 1 | ||
| SKA | MDSD | Santo Domingo - Las Americas Intl | TNCM | St Maarten I - Princess Juliana Intl | Local | 374.5 | 0 | ||
| UFA | MDSD | Santo Domingo - Las Americas Intl | VHHH | Hong Kong Intl | Long | 8346.7 | 0 | ||
| UFA | MDSD | Santo Domingo - Las Americas Intl | YPDN | Darwin Intl | Long | 9559.1 | 0 | ||
| UFA | MDSD | Santo Domingo - Las Americas Intl | KDTW | Detroit Metro Wayne Co | Medium | 1588.5 | 0 | ||
| UFA | MDSD | Santo Domingo - Las Americas Intl | SBGL | Rio De Janeiro - Galeao-Antonio C Jobim Intl | Medium | 2919.1 | 0 | ||
| UFA | MDSD | Santo Domingo - Las Americas Intl | KLAX | Los Angeles Intl | Medium | 2755.6 | 1 | ||
| UFA | MDSD | Santo Domingo - Las Americas Intl | KJFK | New York - Kennedy Intl | Medium | 1349.3 | 0 | ||
| UFA | MDSD | Santo Domingo - Las Americas Intl | KSEA | Seattle-Tacoma Intl | Long | 3091.4 | 0 | ||
| UFA | MDSD | Santo Domingo - Las Americas Intl | LFPG | Paris - Charles-De-Gaulle | Long | 3876.9 | 1 |