| VA | From | Airport | To | Destination | Type | Distance miles | Frequency | Competitors | |
|---|---|---|---|---|---|---|---|---|---|
| AAA | MPTO | Panama City - Tocumen Intl | TNCM | St Maarten I - Princess Juliana Intl | Medium | 1090.0 | 0 | ||
| AAA | MPTO | Panama City - Tocumen Intl | KMCO | Orlando Intl | Medium | 1166.6 | 1 | ||
| ACF | MPTO | Panama City - Tocumen Intl | SBCG | Campo Grande Intl | Medium | 2295.2 | 1 | ||
| ACF | MPTO | Panama City - Tocumen Intl | SELT | Latacunga - Cotopaxi Intl | Regional | 600.5 | 2 | ||
| ACF | MPTO | Panama City - Tocumen Intl | TNCA | Aruba I - Oranjestad/Reina Beatrix Intl | Regional | 589.2 | 0 | ||
| AEU | MPTO | Panama City - Tocumen Intl | KORD | Chicago-OHare Intl | Medium | 2025.1 | 1 | ||
| AEU | MPTO | Panama City - Tocumen Intl | RKSS | Seoul - Kimpo Intl | Long | 7639.8 | 2 | ||
| AEU | MPTO | Panama City - Tocumen Intl | PANC | Stevens Anchorage Intl | Long | 4366.3 | 1 | ||
| AEU | MPTO | Panama City - Tocumen Intl | KDLH | Duluth Intl | Medium | 2359.0 | 1 | ||
| AEU | MPTO | Panama City - Tocumen Intl | LSZH | Zurich | Long | 4916.2 | 0 | ||
| AEU | MPTO | Panama City - Tocumen Intl | RJGG | Chubu Centrair International | Long | 7459.4 | 3 | ||
| AEU | MPTO | Panama City - Tocumen Intl | NZAA | Auckland Intl | Long | 6483.4 | 1 | ||
| AEU | MPTO | Panama City - Tocumen Intl | VHHH | Hong Kong Intl | Long | 8761.2 | 0 | ||
| AEU | MPTO | Panama City - Tocumen Intl | OMDB | Dubai Intl | Long | 7449.5 | 0 | ||
| AEU | MPTO | Panama City - Tocumen Intl | OMAA | Abu Dhabi Intl | Long | 7442.2 | 1 | ||
| AVL | MPTO | Panama City - Tocumen Intl | LSZH | Zurich | Long | 4916.2 | 1 | ||
| AVL | MPTO | Panama City - Tocumen Intl | KLAX | Los Angeles Intl | Medium | 2614.5 | 0 | ||
| AVL | MPTO | Panama City - Tocumen Intl | KORD | Chicago-OHare Intl | Medium | 2025.1 | 1 | ||
| CFC | MPTO | Panama City - Tocumen Intl | MPHO | Balboa - Howard AFB | Local | 15.7 | 5 | ||
| CFC | MPTO | Panama City - Tocumen Intl | MSLP | San Salvador - El Salvador Intl | Regional | 626.6 | 4 | ||
| CFC | MPTO | Panama City - Tocumen Intl | RJGG | Chubu Centrair International | Long | 7459.4 | 2 | ||
| CFC | MPTO | Panama City - Tocumen Intl | RKSS | Seoul - Kimpo Intl | Long | 7639.8 | 3 | ||
| CFC | MPTO | Panama City - Tocumen Intl | NZAA | Auckland Intl | Long | 6483.4 | 3 | ||
| EVO | MPTO | Panama City - Tocumen Intl | VHHX | Hong Kong Intl (old) | Long | 8754.2 | 0 | ||
| EVO | MPTO | Panama City - Tocumen Intl | EHAM | Amsterdam - Schiphol | Long | 4755.7 | 0 | ||
| EVO | MPTO | Panama City - Tocumen Intl | SPRU | Trujillo - Cap Carlos Martinez De Pinill | Medium | 1029.5 | 0 | ||
| EVO | MPTO | Panama City - Tocumen Intl | MMIT | Ixtepec | Medium | 1019.5 | 0 | ||
| EVO | MPTO | Panama City - Tocumen Intl | NCRG | Rarotonga Intl | Long | 5068.3 | 0 | ||
| IFR | MPTO | Panama City - Tocumen Intl | SEGU | Guayaquil - Simon Bolivar Intl | Regional | 674.4 | 0 | ||
| IFR | MPTO | Panama City - Tocumen Intl | KPIE | St Petersburg-Clearwater Intl | Medium | 1145.7 | 1 | ||
| IFR | MPTO | Panama City - Tocumen Intl | SVCS | Charallave - Oscar Machado Zuloaga Intl | Regional | 746.9 | 0 | ||
| IFR | MPTO | Panama City - Tocumen Intl | TNCM | St Maarten I - Princess Juliana Intl | Medium | 1090.0 | 1 | ||
| OSA | MPTO | Panama City - Tocumen Intl | SKPB | Portete - Puerto Bolivar | Local | 475.4 | 0 | ||
| OSA | MPTO | Panama City - Tocumen Intl | TFFR | Pointe-A-Pitre - Le Raizet | Medium | 1130.0 | 0 | ||
| OSA | MPTO | Panama City - Tocumen Intl | MNMG | Managua - Augusto Cesar Sandino | Local | 440.5 | 1 | ||
| OSA | MPTO | Panama City - Tocumen Intl | TGPY | St Georges - Point Salines Intl | Medium | 1052.6 | 0 | ||
| RBV | MPTO | Panama City - Tocumen Intl | RKSS | Seoul - Kimpo Intl | Long | 7639.8 | 0 | ||
| RBV | MPTO | Panama City - Tocumen Intl | NZAA | Auckland Intl | Long | 6483.4 | 1 | ||
| RBV | MPTO | Panama City - Tocumen Intl | RJGG | Chubu Centrair International | Long | 7459.4 | 1 | ||
| RBV | MPTO | Panama City - Tocumen Intl | EGCC | Manchester | Long | 4502.9 | 0 | ||
| RED | MPTO | Panama City - Tocumen Intl | SPIM | Lima-Callao - Jorge Chavez Intl | Medium | 1272.8 | 0 | ||
| RED | MPTO | Panama City - Tocumen Intl | KMIA | Miami Intl | Medium | 1004.6 | 0 | ||
| RSQ | MPTO | Panama City - Tocumen Intl | LSZH | Zurich | Long | 4916.2 | 0 | ||
| SCA | MPTO | Panama City - Tocumen Intl | SKBO | Santafe De Bogota - Eldorado Intl | Local | 407.7 | 1 | ||
| SCA | MPTO | Panama City - Tocumen Intl | SKRG | Rionegro - Jose Maria Cordova | Local | 293.0 | 0 | ||
| SCA | MPTO | Panama City - Tocumen Intl | KMIA | Miami Intl | Medium | 1004.6 | 2 | ||
| SKA | MPTO | Panama City - Tocumen Intl | ELLX | Luxembourg | Long | 4815.1 | 1 | ||
| SKA | MPTO | Panama City - Tocumen Intl | SBSV | Salvador - Dep. L. E. Magalhaes Intl | Medium | 2779.6 | 0 | ||
| SKA | MPTO | Panama City - Tocumen Intl | RJGG | Chubu Centrair International | Long | 7459.4 | 1 | ||
| SKA | MPTO | Panama City - Tocumen Intl | MROC | San Jose - Juan Santamaria Intl | Local | 290.8 | 1 | ||
| SKA | MPTO | Panama City - Tocumen Intl | KJFK | New York - Kennedy Intl | Medium | 1917.5 | 0 | ||
| SKA | MPTO | Panama City - Tocumen Intl | EHAM | Amsterdam - Schiphol | Long | 4755.7 | 0 | ||
| SKA | MPTO | Panama City - Tocumen Intl | FJDG | Diego Garcia Navy | Long | 9122.0 | 0 | ||
| SKA | MPTO | Panama City - Tocumen Intl | NZAA | Auckland Intl | Long | 6483.4 | 1 | ||
| SKA | MPTO | Panama City - Tocumen Intl | KIAD | Washington Dulles Intl | Medium | 1795.4 | 1 | ||
| SKA | MPTO | Panama City - Tocumen Intl | SCEL | Santiago - Arturo Merino Benitez Intl | Medium | 2594.5 | 1 | ||
| TKA | MPTO | Panama City - Tocumen Intl | PANC | Stevens Anchorage Intl | Long | 4366.3 | 1 | ||
| TKA | MPTO | Panama City - Tocumen Intl | KJFK | New York - Kennedy Intl | Medium | 1917.5 | 2 | ||
| TKA | MPTO | Panama City - Tocumen Intl | RKSS | Seoul - Kimpo Intl | Long | 7639.8 | 0 | ||
| TKA | MPTO | Panama City - Tocumen Intl | RJGG | Chubu Centrair International | Long | 7459.4 | 0 | ||
| TKA | MPTO | Panama City - Tocumen Intl | NZAA | Auckland Intl | Long | 6483.4 | 4 |