| VA | From | Airport | To | Destination | Type | Distance miles | Frequency | Competitors | |
|---|---|---|---|---|---|---|---|---|---|
| CIF | MUCU | Santiago De Cuba - Antonio Maceo Intl | SAZN | Neuquen - Presidente Peron | Long | 3561.4 | 0 | ||
| CIF | MUCU | Santiago De Cuba - Antonio Maceo Intl | LFPG | Paris - Charles-De-Gaulle | Long | 4052.8 | 2 | ||
| CIF | MUCU | Santiago De Cuba - Antonio Maceo Intl | NTAA | Tahiti I - Faaa | Long | 4891.6 | 0 | ||
| EVO | MUCU | Santiago De Cuba - Antonio Maceo Intl | KDAB | Daytona Beach Intl | Regional | 621.5 | 0 | ||
| EVO | MUCU | Santiago De Cuba - Antonio Maceo Intl | KSAV | Savannah Intl | Regional | 784.4 | 0 | ||
| EVO | MUCU | Santiago De Cuba - Antonio Maceo Intl | MUHG | Holguin - Frank Pais | Local | 55.9 | 0 | ||
| EVO | MUCU | Santiago De Cuba - Antonio Maceo Intl | MKJP | Kingston - Norman Manley Intl | Local | 133.5 | 0 | ||
| FAA | MUCU | Santiago De Cuba - Antonio Maceo Intl | MYNN | Nassau Intl | Local | 317.3 | 0 | ||
| IFR | MUCU | Santiago De Cuba - Antonio Maceo Intl | MYAF | Andros Island - Andros Town Intl | Local | 304.0 | 0 | ||
| IFR | MUCU | Santiago De Cuba - Antonio Maceo Intl | MKJS | Montego Bay - Sangster Intl | Local | 147.0 | 0 | ||
| NAE | MUCU | Santiago De Cuba - Antonio Maceo Intl | SPRU | Trujillo - Cap Carlos Martinez De Pinill | Medium | 1694.4 | 2 | ||
| NAE | MUCU | Santiago De Cuba - Antonio Maceo Intl | TFFR | Pointe-A-Pitre - Le Raizet | Regional | 845.4 | 0 | ||
| SAA | MUCU | Santiago De Cuba - Antonio Maceo Intl | MUCC | MUCC | Local | 204.4 | 1 | ||
| SAA | MUCU | Santiago De Cuba - Antonio Maceo Intl | TNCM | St Maarten I - Princess Juliana Intl | Regional | 731.0 | 1 | ||
| SAA | MUCU | Santiago De Cuba - Antonio Maceo Intl | SBNT | Natal - Augusto Severo Intl | Medium | 2853.6 | 0 |