| VA | From | Airport | To | Destination | Type | Distance miles | Frequency | Competitors | |
|---|---|---|---|---|---|---|---|---|---|
| EVO | MUHG | Holguin - Frank Pais | MUCU | Santiago De Cuba - Antonio Maceo Intl | Local | 55.9 | 0 | ||
| EVO | MUHG | Holguin - Frank Pais | MUGV | MUGV | Local | 33.8 | 0 | ||
| SAA | MUHG | Holguin - Frank Pais | MDPC | Higuey - Punta Cana Intl | Local | 468.5 | 0 | ||
| SAA | MUHG | Holguin - Frank Pais | MYGF | Freeport - Grand Bahama Intl | Local | 370.2 | 1 |