| VA | From | Airport | To | Destination | Type | Distance miles | Frequency | Competitors | |
|---|---|---|---|---|---|---|---|---|---|
| RSQ | SBSM | Santa Maria | SBGL | Rio De Janeiro - Galeao-Antonio C Jobim Intl | Regional | 697.3 | 1 | ||
| RSQ | SBSM | Santa Maria | SOCA | Cayenne - Rochambeau | Medium | 2073.2 | 0 | ||
| RSQ | SBSM | Santa Maria | HTDA | Dar-Es-Salaam Intl | Long | 5345.7 | 1 | ||
| RSQ | SBSM | Santa Maria | KSFO | San Francisco Intl | Long | 5580.3 | 0 | ||
| RSQ | SBSM | Santa Maria | FAOR | Johannesburg Intl | Long | 4252.2 | 0 | ||
| RSQ | SBSM | Santa Maria | EDDF | Frankfurt/Main | Long | 5814.2 | 2 | ||
| RSQ | SBSM | Santa Maria | NZAA | Auckland Intl | Long | 5957.3 | 0 | ||
| RSQ | SBSM | Santa Maria | SAEZ | Buenos Aires - Ezeiza Intl Ministro Pistarin | Local | 392.9 | 2 | ||
| SKA | SBSM | Santa Maria | KLAX | Los Angeles Intl | Long | 5293.4 | 1 | ||
| SKA | SBSM | Santa Maria | EDDF | Frankfurt/Main | Long | 5814.2 | 0 | ||
| SKA | SBSM | Santa Maria | SAEZ | Buenos Aires - Ezeiza Intl Ministro Pistarin | Local | 392.9 | 1 | ||
| SKA | SBSM | Santa Maria | KSEA | Seattle-Tacoma Intl | Long | 5921.0 | 1 | ||
| SKA | SBSM | Santa Maria | KSFO | San Francisco Intl | Long | 5580.3 | 1 | ||
| SKA | SBSM | Santa Maria | SBNT | Natal - Augusto Severo Intl | Medium | 1768.5 | 1 | ||
| SKA | SBSM | Santa Maria | FACT | Cape Town Intl | Long | 3616.0 | 1 | ||
| SKA | SBSM | Santa Maria | SBGL | Rio De Janeiro - Galeao-Antonio C Jobim Intl | Regional | 697.3 | 0 | ||
| SKA | SBSM | Santa Maria | FAOR | Johannesburg Intl | Long | 4252.2 | 0 |