| VA | From | Airport | To | Destination | Type | Distance miles | Frequency | Competitors | |
|---|---|---|---|---|---|---|---|---|---|
| FAA | SEGU | Guayaquil - Simon Bolivar Intl | EGSS | London - Stansted | Long | 5137.7 | 1 | ||
| FAA | SEGU | Guayaquil - Simon Bolivar Intl | EGKK | London - Gatwick | Long | 5114.9 | 0 | ||
| FAA | SEGU | Guayaquil - Simon Bolivar Intl | EGLL | London - Heathrow | Long | 5108.2 | 0 | ||
| FAA | SEGU | Guayaquil - Simon Bolivar Intl | EGNX | East Midlands | Long | 5090.9 | 0 | ||
| IFR | SEGU | Guayaquil - Simon Bolivar Intl | SOCA | Cayenne - Rochambeau | Medium | 1702.1 | 0 | ||
| IFR | SEGU | Guayaquil - Simon Bolivar Intl | KATL | The Hartsfield Atlanta Intl | Medium | 2163.2 | 0 | ||
| IFR | SEGU | Guayaquil - Simon Bolivar Intl | SBRF | Recife - Guararapes Intl | Medium | 2708.7 | 0 | ||
| IFR | SEGU | Guayaquil - Simon Bolivar Intl | SAWH | Ushuaia Intl Malvine Is | Long | 3211.5 | 0 | ||
| IFR | SEGU | Guayaquil - Simon Bolivar Intl | SAEZ | Buenos Aires - Ezeiza Intl Ministro Pistarin | Medium | 2293.6 | 0 | ||
| IFR | SEGU | Guayaquil - Simon Bolivar Intl | MPTO | Panama City - Tocumen Intl | Regional | 674.4 | 1 | ||
| KSA | SEGU | Guayaquil - Simon Bolivar Intl | KBOS | Boston - Logan Intl | Medium | 2714.4 | 1 | ||
| UCA | SEGU | Guayaquil - Simon Bolivar Intl | LFML | Marseille/Provence | Long | 5275.9 | 0 | ||
| UCA | SEGU | Guayaquil - Simon Bolivar Intl | UKBB | Kyiv - Boryspil | Long | 6287.2 | 1 | ||
| USA | SEGU | Guayaquil - Simon Bolivar Intl | KORD | Chicago-OHare Intl | Medium | 2683.9 | 0 |