| VA | From | Airport | To | Destination | Type | Distance miles | Frequency | Competitors | |
|---|---|---|---|---|---|---|---|---|---|
| EVO | SEMT | Manta - Eloy Alfaro Intl | SPTP | El Pato AB | Local | 218.7 | 0 | ||
| EVO | SEMT | Manta - Eloy Alfaro Intl | SETN | Tachina - General Rivadeneira | Local | 131.6 | 0 | ||
| NAE | SEMT | Manta - Eloy Alfaro Intl | KMIA | Miami Intl | Medium | 1604.5 | 0 | ||
| NAE | SEMT | Manta - Eloy Alfaro Intl | SBGL | Rio De Janeiro - Galeao-Antonio C Jobim Intl | Medium | 2544.7 | 2 | ||
| PIA | SEMT | Manta - Eloy Alfaro Intl | SPRU | Trujillo - Cap Carlos Martinez De Pinill | Local | 438.5 | 0 | ||
| PIA | SEMT | Manta - Eloy Alfaro Intl | NSFA | Apia - Faleolo Intl | Long | 5463.2 | 1 | ||
| USA | SEMT | Manta - Eloy Alfaro Intl | UKKK | Kyiv - Zhuliany | Long | 6241.9 | 0 |