| VA | From | Airport | To | Destination | Type | Distance miles | Frequency | Competitors | |
|---|---|---|---|---|---|---|---|---|---|
| AVL | TJSJ | San Juan - Luis Munoz Marin Intl | MKJP | Kingston - Norman Manley Intl | Regional | 615.5 | 0 | ||
| AVL | TJSJ | San Juan - Luis Munoz Marin Intl | KEWR | Newark Intl | Medium | 1399.9 | 0 | ||
| AVL | TJSJ | San Juan - Luis Munoz Marin Intl | TNCM | St Maarten I - Princess Juliana Intl | Local | 166.5 | 0 | ||
| AVL | TJSJ | San Juan - Luis Munoz Marin Intl | MTPP | Port-Au-Prince Intl | Local | 358.2 | 1 | ||
| AVL | TJSJ | San Juan - Luis Munoz Marin Intl | KMIA | Miami Intl | Regional | 907.6 | 2 | ||
| AVL | TJSJ | San Juan - Luis Munoz Marin Intl | KORD | Chicago-OHare Intl | Medium | 1801.0 | 1 | ||
| AVL | TJSJ | San Juan - Luis Munoz Marin Intl | KLAX | Los Angeles Intl | Medium | 2936.9 | 1 | ||
| AVL | TJSJ | San Juan - Luis Munoz Marin Intl | MYGF | Freeport - Grand Bahama Intl | Regional | 854.9 | 1 | ||
| CFC | TJSJ | San Juan - Luis Munoz Marin Intl | KJFK | New York - Kennedy Intl | Medium | 1391.0 | 3 | ||
| CFC | TJSJ | San Juan - Luis Munoz Marin Intl | TXKF | Bermuda Is - Bermuda Intl | Regional | 838.5 | 2 | ||
| CFC | TJSJ | San Juan - Luis Munoz Marin Intl | KMIA | Miami Intl | Regional | 907.6 | 3 | ||
| EVO | TJSJ | San Juan - Luis Munoz Marin Intl | VHHX | Hong Kong Intl (old) | Long | 8354.6 | 0 | ||
| EVO | TJSJ | San Juan - Luis Munoz Marin Intl | TIST | St Thomas I/Charlotte A - King | Local | 58.9 | 0 | ||
| EVO | TJSJ | San Juan - Luis Munoz Marin Intl | TNCM | St Maarten I - Princess Juliana Intl | Local | 166.5 | 0 | ||
| FTS | TJSJ | San Juan - Luis Munoz Marin Intl | TISX | St Croix I - Henry E Rohlsen | Local | 81.7 | 1 | ||
| IFR | TJSJ | San Juan - Luis Munoz Marin Intl | MDSD | Santo Domingo - Las Americas Intl | Local | 208.7 | 0 | ||
| IFR | TJSJ | San Juan - Luis Munoz Marin Intl | TNCM | St Maarten I - Princess Juliana Intl | Local | 166.5 | 0 | ||
| JUL | TJSJ | San Juan - Luis Munoz Marin Intl | TIST | St Thomas I/Charlotte A - King | Local | 58.9 | 2 | ||
| JUL | TJSJ | San Juan - Luis Munoz Marin Intl | MDPP | Puerto Plata - Gregorio Luperon Intl | Local | 270.8 | 1 | ||
| JUL | TJSJ | San Juan - Luis Munoz Marin Intl | MDPC | Higuey - Punta Cana Intl | Local | 134.6 | 0 | ||
| JUL | TJSJ | San Juan - Luis Munoz Marin Intl | TFFG | St Martin I - Grand Case | Local | 169.5 | 0 | ||
| JUL | TJSJ | San Juan - Luis Munoz Marin Intl | TFFJ | St Barthelemy I | Local | 182.9 | 0 | ||
| JUL | TJSJ | San Juan - Luis Munoz Marin Intl | TNCM | St Maarten I - Princess Juliana Intl | Local | 166.5 | 0 | ||
| RSQ | TJSJ | San Juan - Luis Munoz Marin Intl | PAFA | Fairbanks Intl | Long | 4194.8 | 1 | ||
| RSQ | TJSJ | San Juan - Luis Munoz Marin Intl | LHBP | Budapest - Ferihegy | Long | 4403.0 | 0 | ||
| SKA | TJSJ | San Juan - Luis Munoz Marin Intl | PANC | Stevens Anchorage Intl | Long | 4262.2 | 1 | ||
| SKA | TJSJ | San Juan - Luis Munoz Marin Intl | KORD | Chicago-OHare Intl | Medium | 1801.0 | 0 | ||
| SKA | TJSJ | San Juan - Luis Munoz Marin Intl | SBKP | Campinas - Viracopos Intl | Medium | 2721.6 | 0 | ||
| SKA | TJSJ | San Juan - Luis Munoz Marin Intl | SEQM | Quito Aeropuerto Internacional Mariscal Sucre | Medium | 1331.7 | 0 | ||
| SKA | TJSJ | San Juan - Luis Munoz Marin Intl | KMIA | Miami Intl | Regional | 907.6 | 0 | ||
| SKA | TJSJ | San Juan - Luis Munoz Marin Intl | KMSP | Minneapolis-St Paul Intl | Medium | 2089.1 | 2 | ||
| SKA | TJSJ | San Juan - Luis Munoz Marin Intl | SBGL | Rio De Janeiro - Galeao-Antonio C Jobim Intl | Medium | 2811.5 | 0 | ||
| SKA | TJSJ | San Juan - Luis Munoz Marin Intl | TNCA | Aruba I - Oranjestad/Reina Beatrix Intl | Local | 425.1 | 1 | ||
| SKA | TJSJ | San Juan - Luis Munoz Marin Intl | TNCM | St Maarten I - Princess Juliana Intl | Local | 166.5 | 0 | ||
| SKA | TJSJ | San Juan - Luis Munoz Marin Intl | TIST | St Thomas I/Charlotte A - King | Local | 58.9 | 3 | ||
| SSF | TJSJ | San Juan - Luis Munoz Marin Intl | KLAX | Los Angeles Intl | Medium | 2936.9 | 0 | ||
| SSF | TJSJ | San Juan - Luis Munoz Marin Intl | YSSY | Sydney - Kingsford Smith Intl | Long | 8608.8 | 0 | ||
| SSF | TJSJ | San Juan - Luis Munoz Marin Intl | EDDL | Dusseldorf | Long | 3899.8 | 0 | ||
| SSF | TJSJ | San Juan - Luis Munoz Marin Intl | KSEA | Seattle-Tacoma Intl | Long | 3235.3 | 0 | ||
| SSF | TJSJ | San Juan - Luis Munoz Marin Intl | PANC | Stevens Anchorage Intl | Long | 4262.2 | 0 | ||
| SSF | TJSJ | San Juan - Luis Munoz Marin Intl | KMIA | Miami Intl | Regional | 907.6 | 0 | ||
| UFA | TJSJ | San Juan - Luis Munoz Marin Intl | TFFR | Pointe-A-Pitre - Le Raizet | Local | 287.6 | 1 |